Allergies
https://pubmed.ncbi.nlm.nih.gov/19766097/
Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells.
Alzheimer's
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224395/ Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
Anti-inflammatory / Anti-Oxidant properties
https://pubmed.ncbi.nlm.nih.gov/23031079/ Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788323/ Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases
https://pubmed.ncbi.nlm.nih.gov/11510417/ Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871940/ Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376192/ Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988658/ Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096066/ Anti-inflammatory and antitumor action of hydrogen via reactive oxygen species
https://pubmed.ncbi.nlm.nih.gov/30243702/Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045005/ Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095341/ (2016) Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress
https://www.sciencedirect.com/science/article/pii/S1567576914002124?ref=pdf_download (2014) Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563451/ (2012) Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study
https://www.spandidos-publications.com/10.3892/etm.2018.6880 (2018) Beneficial Effects of Hydrogen Gas Inhalation on a Murine Model of Allergic Rhinitis
Antioxidant & Brain Protection
https://pubmed.ncbi.nlm.nih.gov/17486089/Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694409/Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865993/A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057981/Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
https://pubmed.ncbi.nlm.nih.gov/28669654/Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664236/
Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087877/Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring
Asthma-Allergic Inflammation
https://www.nature.com/articles/s41598-020-58999-0 Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch Scientific
https://www.sciencedirect.com/science/article/abs/pii/S1567576918313638 Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model
Athletic & Muscle Performance
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395574/ Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes
https://pubmed.ncbi.nlm.nih.gov/28474871/Effects of hydrogen rich water on prolonged intermittent exercise
https://pubmed.ncbi.nlm.nih.gov/25295663/Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837388/ Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice
Bioavailability & Inhalation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731988/ Molecular hydrogen: a preventive and therapeutic medical gas for various diseases
https://pubmed.ncbi.nlm.nih.gov/21621588/Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases
https://pubmed.ncbi.nlm.nih.gov/17486089/Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
https://pubmed.ncbi.nlm.nih.gov/18563058/Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice
https://pubmed.ncbi.nlm.nih.gov/24769081/Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
https://pubmed.ncbi.nlm.nih.gov/28669654/Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection
Cancer
https://www.mdpi.com/1422-0067/22/16/8724 Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression
https://www.sciencedirect.com/science/article/pii/S0163725814000941?via%3Dihub Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
https://www.mdpi.com/2571-8797/2/4/33 Hydrogen Is Promising for Medical Applications
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123813/ Molecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805896/ Hydrogen as a New Class of Radioprotective Agent
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189362/ Hydrogen gas represses the progression of lung cancer via down-regulating CD47
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885710/ Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092147/ Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448556/ Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691140/ Hydrogen Gas in Cancer Treatment
https://pdfs.semanticscholar.org/cf12/d0164bf19ab13b57594757554c3b52a4df04.pdf Neutral pH Hydrogen-Enriched Electrolyzed Water Achieves Tumor-Preferential Clonal Growth Inhibition Over Normal Cells and Tumor Invasion Inhibition Concurrently With Intracellular Oxidant Repression
https://pubmed.ncbi.nlm.nih.gov/19783965/Platinum nanocolloid-supplemented hydrogendissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells
https://pubmed.ncbi.nlm.nih.gov/21042740/Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death
https://www.tandfonline.com/doi/full/10.3109/10715762.2015.1131823 Transient generation of hydrogen peroxide is responsible for carcinostatic effects of hydrogen combined with platinum nanocolloid, together with increases intracellular ROS, DNA cleavages, and proportion of G2/M-phase
https://pubmed.ncbi.nlm.nih.gov/33387361/Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen
https://www.scientific.net/MSF.706-709.520 Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells
https://peerj.com/articles/859/ Hydrogen–water enhances 5-fluorouracil-induced inhibition of colon cancer
https://www.sciencedirect.com/science/article/abs/pii/S0753332218308667?via%3Dihub Hydrogen gas inhibits lung cancer progression through targeting SMC3
https://pubmed.ncbi.nlm.nih.gov/31113492/Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
https://pubmed.ncbi.nlm.nih.gov/31924176/Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.25782 Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice†
https://www.jstage.jst.go.jp/article/bpb/31/1/31_1_19/_article Inhibitory Effect of Electrolyzed Reduced Water on Tumor Angiogenesis
https://www.spandidos-publications.com/10.3892/or.2018.6841 Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis
https://www.spandidos-publications.com/10.3892/ol.2020.12121 Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD‑1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
https://pubmed.ncbi.nlm.nih.gov/31552873/"Real world survey" of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients
https://www.sciencedirect.com/science/article/pii/S0163725814000941?via%3Dihub Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
https://www.mdpi.com/1422-0067/22/5/2549 Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress
https://www.wjgnet.com/2307-8960/full/v7/i15/2065.htm Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report
https://www.dovepress.com/a-gallbladder-carcinoma-patient-with-pseudo-progressive-remission-afte-peer-reviewed-fulltext-article-OTT A Gallbladder Carcinoma Patient With Pseudo-Progressive Remission After Hydrogen Inhalation
https://www.dovepress.com/brain-metastases-completely-disappear-in-non-small-cell-lung-cancer-us-peer-reviewed-fulltext-article-OTT Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
https://journals.lww.com/mgar/fulltext/2020/10020/hydrogen_therapy_can_be_used_to_control_tumor.5.aspx Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer
https://www.sciencedirect.com/science/article/abs/pii/S0753332218308667?via%3DihubHydrogen gas inhibits lung cancer progression through targeting SMC3
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1241-x Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-6491-6 Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
https://www.jstage.jst.go.jp/article/bpb/31/1/31_1_19/_article Inhibitory Effect of Electrolyzed Reduced Water on Tumor Angiogenesis
https://www.ingentaconnect.com/content/tsp/or/2008/00000017/00000006/art00002;jsessionid=5kbn5mmmbtcs1.x-ic-live-03 Neutral pH Hydrogen-Enriched Electrolyzed Water Achieves Tumor-Preferential Clonal Growth Inhibition Over Normal Cells and Tumor Invasion Inhibition Concurrently With Intracellular Oxidant Repression
https://pubmed.ncbi.nlm.nih.gov/21042740/Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death
https://www.tandfonline.com/doi/full/10.3109/10715762.2015.1131823 Transient generation of hydrogen peroxide is responsible for carcinostatic effects of hydrogen combined with platinum nanocolloid, together with increases intracellular ROS, DNA cleavages, and proportion of G2/M-phase
https://link.springer.com/article/10.1007/s13577-020-00462-3 Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen
https://www.ajol.info/index.php/tjpr/article/view/164283 Potential protective role of hydrogen against cisplatininduced side effects during chemotherapy: A mini-review of a novel hypothesis for antagonism of hydrogen
https://pubmed.ncbi.nlm.nih.gov/29142752/Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy
https://pubmed.ncbi.nlm.nih.gov/19249288/Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats
https://pubmed.ncbi.nlm.nih.gov/18996093/Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice
https://www.spandidos-publications.com/10.3892/or.2018.6841Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis
https://www.researchsquare.com/article/rs-201468/v1 Investigating the Effect of Hydrogen-Rich Water on Liver Cell Injury and Liver Cancer by Regulating GP73/ TGF-β Pathway
https://www.spandidos-publications.com/10.3892/or.2021.8092Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-6491-6 Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
https://onlinelibrary.wiley.com/doi/10.1155/2022/8024452 Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway
https://www.spandidos-publications.com/10.3892/or.2018.6841Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis
https://pubmed.ncbi.nlm.nih.gov/19148645/Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice
https://pubmed.ncbi.nlm.nih.gov/20505032/Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT
https://pubmed.ncbi.nlm.nih.gov/22146004/Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
https://pubmed.ncbi.nlm.nih.gov/32541132/Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer
https://pubmed.ncbi.nlm.nih.gov/26668628/Hydrogen-rich saline attenuates chemotherapy-induced ovarian injury via regulation of oxidative stress
https://www.nature.com/articles/nm1577Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666661/ Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy
Cardiovascular disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600250/ A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353690/ Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555031/ Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239052/ Hydrogen therapy as a potential therapeutic intervention in heart disease: from the past evidence to future application
https://pubmed.ncbi.nlm.nih.gov/25979689%20 Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice
COPD
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120708/ Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel group controlled trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7785302/ Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051853/ Hydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108576/ Hydrogen Therapy may be a Novel and Effective Treatment for COPD
COVID
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8569706/ (2121) Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896485/ Hydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872486/ Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330772/ Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial
Diabetes
https://pubmed.ncbi.nlm.nih.gov/19083400/Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542317/ (2013) Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542317/ (2020) Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889559/ (2023) Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9515190/ Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291681/ Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754517/ Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes
Eye Protection
https://pubmed.ncbi.nlm.nih.gov/19834032/Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury
https://pubmed.ncbi.nlm.nih.gov/20847117/Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model
https://pubmed.ncbi.nlm.nih.gov/25801048/Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina
Gut Health
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231938/ Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679390/ Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799803/ Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota
Hearing Loss
https://pubmed.ncbi.nlm.nih.gov/19339905/Hydrogen protects auditory hair cells from free radicals
https://pubmed.ncbi.nlm.nih.gov/22387110/Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063935/ Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect
Hormone Health
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178641/ Emerging mechanisms and novel applications of hydrogen gas therapy
https://pubmed.ncbi.nlm.nih.gov/28560519/Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141176/ Therapeutic Potential of Molecular Hydrogen in Metabolic Diseases from Bench to Bedside
Hypertension
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585236/ (2022) The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692487/ Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension
https://pubmed.ncbi.nlm.nih.gov/30259991/Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation
Immune System
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376192/ Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567800/ Recent Advances in Studies of Molecular Hydrogen against Sepsis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560832/ Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495244/ Hydrogen: A Novel Option in Human Disease Treatment
Liver Health
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350887/ Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B
https://pubmed.ncbi.nlm.nih.gov/23682614/Effects of oral intake of hydrogen water on liver fibrogenesis in mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350887/ Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196827/ A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002796/ Hydrogen treatment: a novel option in liver diseases
Metabolic / Weight Management
https://onlinelibrary.wiley.com/doi/10.1038/oby.2011.6 Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967957/ The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679390/ Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
Mood Disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812321/ Effects of hydrogen-rich water on depressive-like behavior in mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409143/ Molecular Hydrogen Reduces LPS-Induced Neuroinflammation and Promotes Recovery from Sickness Behavior in Mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575246/ Molecular hydrogen increases resilience to stress in mice
Parkinson’s
https://hydrogenstudies.com/study/a-randomized-double-blind-multi-center-trial-of-hydrogen-water-for-parkinsons-disease-protocol-and-baseline-characteristics/ A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-016-0589-0 A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics
https://www.sciencedirect.com/science/article/abs/pii/S0304394009001839?via%3DihubMolecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease
Safety / Tolerability
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731988/ Molecular hydrogen: a preventive and therapeutic medical gas for various diseases
https://www.scientific.net/MSF.706-709.520Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells
https://www.sciencedirect.com/science/article/pii/S0163725814000941?via%3DihubMolecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
https://www.mdpi.com/2571-8797/2/4/33 Hydrogen Is Promising for Medical Applications
Skin Health
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407032/ Hydrogen(H2) treatment for acute erythematous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852999/ The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice
Traumatic Brain Injury
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224395/ Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
https://www.tandfonline.com/doi/full/10.1080/01616412.2020.1747717 Hydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3β signal pathway in a microvascular endothelial cell model of traumatic brain injury
https://www.ijcep.com/files/ijcep0042919.pdf Effect of hydrogen-rich water on the angiogenesis in lesion boundary brain tissue of traumatic brain injury-challenged rats
https://www.journalofsurgicalresearch.com/article/S0022-4804(18)30189-6/abstractHydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway
Looking for more research? There are over 2,400 studies on H2 and counting! To dive deeper, check out PubMed, Google Scholar, and the Molecular Hydrogen Institute for the latest findings. You can also visit HydroHeal.com and HydrogenStudies.com or hydrogenwaterstudies.com for additional resources. Pro tip: just type your condition + "molecular hydrogen" to quickly find relevant research.
